解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The purpose of this experiment was to determine whether surgical stress on the morning of proestrus would elicit an early release of gonadotropin from the pituitary. Animals exhibiting 5-day estrous cycles underwent bilateral sham-ovariectomy under ether anesthesia at 0800 h of proestrus. These animals had high levels...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-3-718
更新日期:1975-09-01 00:00:00
abstract::A miniature thermoelectric probe was used to record continuously tissue blood flow in the anterior pituitary gland of anesthetized dogs. The output of the flow probe is linear in the range of tissue blood flow encountered in the pituitary. Probe placement required minimal tissue trauma, and zero blood flow was recorde...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-3-630
更新日期:1975-09-01 00:00:00
abstract::The quantities of estrone and estradiol were determined by radioimmunoassay in maternal and fetal plasma of the rhesus monkey from day 59 to 163 of gestation. A two way analysis of variance of data classified according to fetal sex and 3 pooled gestational ages for each hormone and for mother or fetus (4 analyses) rev...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-2-425
更新日期:1975-08-01 00:00:00
abstract::Central and peripheral humoral responses of the adrenocortical system were measured for 2 h after the application of several stimuli. Two min after the onset of the stresses of sham-adrenalectomy or laparotomy with intestinal traction there was a 4-6 fold increase in hypothalamic CRF content as compared to control con...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-2-265
更新日期:1975-08-01 00:00:00
abstract::Administration of dehydroepiandrosterone (DHA) to immature female rats on day 27 for 3 days resulted in an increase in uterine weight within 6 h of injection and a surge of FSH, LH and prolactin occurred on day 30 resulting in premature ovulation. Increase in ovarian weight and vaginal patency also occurred on day 30....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-2-458
更新日期:1975-08-01 00:00:00
abstract::Human pituitary prolactin (hPRL) contains a single major component. Upon iodination by a lactoperoxidase procedure approximately 50% of this component remains ulaltered in molecular size and net charge by the criteria of quantitative polyacrylamide gel electrophoresis (PAGE). Aminiotic fluid hPRL contains two componen...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-2-406
更新日期:1975-08-01 00:00:00
abstract::The amount of corticosterone bound to proteins in the adenohypophysis and dorsal hippocampus was studied concurrently with the plasma ACTH concentration in 4-week adrenalectomized male rats under steady-state conditions achieved by infusing the steroid at a constant rate for 45 min. Corticosterone binding was measured...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-1-223
更新日期:1975-07-01 00:00:00
abstract::The developmental patterns of thyroid-stimulating hormone (TSH) was examined in female Long-Evans rats by radioimmunoassay of pituitary and plasma from 5 through 80 days of age. The effects of hypothyroidism on normal TSH levels were examined in animals radiothyroidectomized at birth. Control animals showed a peak in ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-1-237
更新日期:1975-07-01 00:00:00
abstract::An in vitro system which uses perifused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 x 10-7M) had no effect on basal gastrin levels but ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-6-1374
更新日期:1975-06-01 00:00:00
abstract::Starvation depresses thyroid gland function. In addition, the peripheral turnover of thyroxine (T4) is reduced, in part due to decreased fecal elimination of T4. The present studies were performed to determine if starvation also affects the deiodinative pathway for T4 degradation. Rats were isotopically equilibrated w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-6-1525
更新日期:1975-06-01 00:00:00
abstract::Tissue levels of bioactive and immunoactive ACTH were measured in both the anterior and neuro-intermediate lobes of the rat pituitary. Similar concentrations of bioactive (65 ng/mg) and immunoactive (83 ng/mg) ACTH were found in the anterior lobes control rats. A 2-min ether stress had no effect on either bioactive or...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-6-1419
更新日期:1975-06-01 00:00:00
abstract::The development of androgen responsiveness in the submandibular gland of normal and androgen-resistant (Tfm) mice of different ages was studied after varying hormonal treatments. Total esteroproteolytic (tamase) activity of submandibular gland homogenates was used as a marker for androgen action. Newborn mice of all f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-6-1571
更新日期:1975-06-01 00:00:00
abstract::The influence of administration of ovine prolactin in vivo on intestinal fluid and ion transport in vitro was investigated using intact and hypophysectomized male rats. Prolactin administration significantly stimulated fluid, sodium,potassium, calcium, magnesium and chloride transport across everted jejunal sacs. The ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-5-1158
更新日期:1975-05-01 00:00:00
abstract::Experiments were carried out to characterize the prolactin stimulation of labeled uridine uptake into mammary gland explants which were initially preincubated for 2 days in medium containing insulin plus hydrocortisone. Prolactin was found to enhance labeled uridine uptake after 4 h but not after 2 h when uridine conc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-5-1307
更新日期:1975-05-01 00:00:00
abstract::Nuclear proteins extracted from purified nuclei with 0.4M KCl at pH 7.4 OR 8.5 are able to bind L-triiodothyronine (T3) giving rise to nuclear thyroid hormone binding protein-T3 (NTBP-T3) complexes. Binding is maximum in 3 h at 20 C. It is thermolabile even at 36 C, inhibited by p-hydroxymercuribenzoate and markedly e...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-5-1201
更新日期:1975-05-01 00:00:00
abstract::In male rats maintained on a 12 h light-dark schedule (6 AM-6 PM), there is a nyctohemeral cycle of plasma prolactin which consists of a nadir at 11:30 AM and an apogee at approximately 11:30 PM. In rats exposed to constant darkness, this rhythm persists for 7 days. Seven days of constant light, however, reverses this...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-5-1230
更新日期:1975-05-01 00:00:00
abstract::Intravenous (i.v.) administration of TRF (1 mg/kg) increases the LD50 of pentobarbital (PB) by 25% while the same dose of somatostatin results in a 30% reduction in PB LD50. A similar increase of PB LD50 by TRF was observed in hypophysectomized rats. Mortality was completely abolished in rats receiving TRF (1 mg/kg) t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-5-1333
更新日期:1975-05-01 00:00:00
abstract::Adrenal cAMP and plasma corticosterone levels were determined in pre-weanling rats subjected to treatment with either ACTH (50 mU/rat) or histamine dihydrochloride (0.2 mg/g body wt). ACTH injection elevated both serum corticosterone and adrenal cAMP levels on all days tested. However, the ACTH-induced elevation of ad...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-4-1044
更新日期:1975-04-01 00:00:00
abstract::The mechanism of the hypophosphatemic effect of thyrocalcitonin (TCT) is uncertain and may involve removal of inorganic phosphate (P1) from the plasma by heretofore unidentified organs. Rats, 192 g. thyroparathyroidectomized 16-24 h earlier, received 100 MRC mU TCT or vehicle (V) SC and 100 muCi 32PO4 iv. One h later ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-4-1048
更新日期:1975-04-01 00:00:00
abstract::The effects of several compounds which interfere with cellular microfilaments and microtubules on the conversion of proparathyroid hormone (ProPTH) to parathyroid hormone (PTH) were examined in slices of bovine parathyroid slices incubated in vitro with 3H-leucine. Inhibitors of microtubular function, vinblastine and ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-4-903
更新日期:1975-04-01 00:00:00
abstract::A proteinaceous secretion from phagocytizing polymorphonuclear leukocytes, termed "leukocytic endogenous mediator" (LEM), has been shown to have marked effects on hepatic amino acid transport and RNA and protein synthesis. A single injection of LEM results in a marked accumulation of labeled nonmetabolizable model ami...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-3-651
更新日期:1975-03-01 00:00:00
abstract::Isolated granulosa cells and theca from proestrous hamsters alone and in recombination, were cultured in order to study steroidogenic capacity of this tissue. Cells from medium size antral follicles (100-300 mum diam.) and large preovulatory follicles (500 plus mum diam.) were used. Steroids were measured by radioimmu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-3-694
更新日期:1975-03-01 00:00:00
abstract::L-Triiodothyronine in vitro increased the uptake of the non-metabolizable amino acid, alpha-aminoisobutyrate, into isolated rat thymocytes. This effect was evident at extracellular free hormone concentrations of 10-7 to 5 times 10-8M and was due to a marked inhibition of amino acid efflux. In contrast, insulin and dib...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-3-802
更新日期:1975-03-01 00:00:00
abstract::A sensitive radioimmunoassay is described for the measurement of plasma concentrations of canine growth hormone (cGH) as low as 0.25 ng/ml. The assay utilizes enzymatically iodinated cGH and the double antibody technique. The mean plasma concentration of growth hormone in the normal dog after overnight fast is 1.75 pl...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-3-822
更新日期:1975-03-01 00:00:00
abstract::A continuous flow incubation (perifusion) system was used to examine the effect of testosterone (T) and three of its 5alpha-reduced metabolites, dihydrotestosterone (DHT), 5alpha-androstane-3alpha, 17beta-diol (3alpha-Adiol) and its 3beta-epimer (3beta-Adiol) on LH and FSH release, induced by hypothalamic extract (HE)...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-2-253
更新日期:1975-02-01 00:00:00
abstract::The ability of ovarian steroids to influence the release of LH was examined after ovariectomy in regularly cycling adult female rats and two types of anovulatory persistent estrous rats: rats treated with 10 mug of testosterone propionate (TP) shortly after birth, and normal rats housed under constant illumination. Tw...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-2-486
更新日期:1975-02-01 00:00:00
abstract::A study was conducted to determine the influence of conditions known to alter ACTH secretion on prolactin release by the pituitary. Dexamethasone or 0.9% NaCl was injected subcutaneously into intact male rats 4 hr before a 2-min ether stress. Other rats were submitted to the ether stress 2 weeks following adrenalectom...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-2-475
更新日期:1975-02-01 00:00:00
abstract::Levels of plasma prolactin were estimated in ovariectomized, estrogen-treated rats following the systemic administration of several neural blocking and stimulating drugs. Phenoxybenzamine, an alpha-adrenergic blocker, at high doses, increased plasma prolactin. Phenotlamine, another alpha-adrenergic blocker, and propra...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-2-313
更新日期:1975-02-01 00:00:00
abstract::Although the extent of proptosis in exophthalmic Graves' disease has been measured directly and shown to correlate with serum content of a bioassayable exophthalmus-producing factor (EPS;1), a comparable relationship in an experimental model has not been reported. Progressive exophthalmos, measured from photographs an...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-151
更新日期:1975-01-01 00:00:00
abstract::With the use of rabbit anti-LH-RH serum, a system of delicate nerve fibers and terminals which contain immunoreactive LH-RH can be demonstrated in the median eminence of the rat, corresponding exactly to the tubero-infundibular tract as described earlier with the aid of classical neurophistological methods. The delica...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-135
更新日期:1975-01-01 00:00:00
abstract::The disappearance of 125-I-ACTH from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. The mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. The higher fetal than mate...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-231
更新日期:1975-01-01 00:00:00
abstract::Immunohistochemical localization of androgen in the testes of both rat and squirrel monkey has been performed using an antiserum specific to testosterone and certain related androgens. The bound antibodies were visualized by coupling with antigammaglobulin labeled either with fluorescein isothiocyanate or with a horse...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-63
更新日期:1975-01-01 00:00:00
abstract::To determine the basis for the marked daily variability in circulating luteinizing hormone (LH) in the female lamb shortly after birth and to determine whether circulating follicle-stimulating hormone (FSH) exhibits similar variability during this period of life, serum levels of both gonadotropins were monitored frequ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-15
更新日期:1975-01-01 00:00:00
abstract::This is an obituary for Gregory Goodwin Pincus whose death in August, 1967, terminated a distinguished career in the biological sciences. His major work was in reproductive biology. This work, in collaboration with Dr. John Rock, led to the development and field testing in Puerto Rico of the 1st OC (oral contracepti...
journal_title:Endocrinology
pub_type: 传,历史文章,杂志文章
doi:10.1210/endo-82-4-651
更新日期:1968-04-01 00:00:00